ENBREL (etanercept) For subcutaneous injection. 

ENBREL is for reducing signs and symptoms of moderately to severely active rheumatoid arthritis; severely active polyarticular juvenile idiopathic arthritis; inhibiting the progression of structural damage of active arthritis, and improving physical function in patients with psoriatic arthritis;  ENBREL® is indicated for reducing signs and symptoms in patients with active ankylosing spondylitis.  It is also  indicated for the treatment of adult patients with chronic moderate to severe plaque psoriasis who are candidates for systemic therapy or phototherapy.

 ENBREL can be initiated in combination with methotrexate (MTX) or used alone.

Side Effects of Enbrel all medicines may cause side effects, but many people have no, or minor side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Enbrel Multiple-Use Vials:

Dizziness; headache; pain, redness, itching, bruising, or swelling around the injection site.

Seek medical attention right away if any of these SEVERE side effects occur when using Enbrel: Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); butterfly rash (rash on nose and cheeks); chest pain or discomfort; decreased mental alertness; fast heartbeat; fever, chills, or sore throat; general feeling of being unwell; mental or mood changes; new or worsening cough; numbness or tingling throughout your body; rapid breathing; rash on your face and arms that gets worse in the sun; seizures; shortness of breath; swelling of arms or legs; swelling of the lymph nodes; unusual bruising or bleeding; unusual lumps; unusual nausea, vomiting, stomach pain, or diarrhea; unusual tiredness; vision problems; weakness in arms or legs.